In a bitterly disappointing contest in front of the Lions’ lowest home league crowd of the season of just 10,183, Preston midfielder Ben Whiteman missed a second-half penalty.
Shaun Hutchinson tangled with Andrew Hughes in the area with Whiteman’s resultant spot-kick coming back off the post in the game’s only real chance.
In League One, AFC Wimbledon picked up a point in their survival battle after fighting back to draw 2-2 with Cheltenham Town at Plough Lane.
Ayoub Assal gave the Dons the lead from a corner in the eighth minute, collecting the ball and driving home a clean strike from a tight angle.
Cheltenham forward Alfie May then struck twice in the space of three minutes to turn the match around just after the half-hour mark, his second coming from the penalty spot.
However, Wimbledon hit back to level with 10 minutes left through substitute Aaron Cosgrave’s low effort.
And in League Two, Leyton Orient were denied a rare away victory with a scrappy 1-1 draw against Bradford City.
Orient, who had lost five of their previous six matches in all competitions and had not scored in five of them, took the lead in the 69th minute through Darren Pratley but were denied maximum points by an Elliot Watt goal six minutes from time.