QPR strengthened their reputation as Championship dark horses this season with an impressive 3-0 win at Hull City.
Chris Willock opened the scoring in the 16th minute following a training ground free-kick routine before Lyndon Dykes turned in another well-rehearsed second after 68 minutes.
Hull then had midfielder George Moncur sent-off for a bad challenge on Dominic Ball before Rob Dickie squeezed the ball home to make it three.
Fulham also put out a statement of intent with a 5-1 thumping of Huddersfield Town.
The Cottagers are aiming for an instant return to the Premier League following relegation last season and put the Terriers to the sword.
A bizarre goal from Aleksandar Mitrovic, after Terriers goalkeeper Ryan Schofield fluffed a clearance, set them on their way with further first-half goals from Joshua Onomah and Fabio Carvalho stamping their authority on the encounter.
Matty Pearson registered for hapless Huddersfield but that was as good as it got, even with Fulham finishing with 10 men after Harry Wilson’s red card as Ivan Cavaleiro’s late double completed the rout.
Meanwhile, Millwall were forced to settle for a point in a 1-1 draw with Blackburn Rovers at The Den.
Ben Brereton’s 76th minute strike cancelled out Jed Wallace’s 64th minute opener for the hosts.
Wallace, top scorer last season for Gary Rowett’s side, also has two goals in two but, just as on the opening day at QPR, Millwall were unable to hold on to their advantage.
In League One, AFC Wimbledon fans’ return to Plough Lane after three decades was marked with a six-goal League One thriller as the Dons drew 3-3 with Bolton.
The home side, once again playing in front of supporters at the ground they originally left in 1991, took the lead through Will Nightingale before an Eoin Doyle penalty levelled the scores.
Wanderers then went 3-1 up with goals from Josh Sheehan and Oladapo Afolayan, before Aaron Pressley converted a penalty and Dapo Mebude scored for Wimbledon to ensure the spoils were shared.
Elsewhere, a Conor Washington penalty was not enough for Charlton Athletic as goals from Ryan Williams and Cameron Brannagan sealed three points for Oxford in a 2-1 win.
In League Two, Leyton Orient picked up their first win of the season as they beat 10-man Exeter 3-0 thanks to goals from Aaron Drinan, Omar Beckles and Theo Archibald.
The O’s were 2-0 up through Drinan and Beckles before O’s keeper Lawrence Vigouroux denied Matt Jay from the spot.
Jonathan Grounds was then handed a second yellow for Exeter before Archibald rounded off the scoring late on.
And finally, Sutton United claimed their first Football League point with a goalless draw away to Salford City.